In 1985 at the music fair in Milan Prophet 2000 was introduced - the first sampler made by SCI. Compared to its predecessors (E-mu Emulator and Ensoniq Mirage), the synthesizer got the sample rate almost twice bigger (12 bits versus 8) and offered quite a low cost.

Prophet 2000 is an 8-voice digital keyboard sampler. The most attracting trait of the synthesizer is in its analog path based on CEM3379 per each voice:

• A voltage controlled low-pass filter (LP VCF) with a four-stage structure (4 poles) with a slope of 24 dB per octave. Adjustment of cutoff frequency, resonance and modulation depth is provided.
• Voltage controlled amplifier (VCA).

To control the VCF and VCA independent ADSR envelope generators are provided.

The sound of Sequential Circuits Prophet 2000 can be heard in Depeche Mode, D:ream, Hardfloor, Information Society, Mark Isham, John Carpenter records.